Top Definition
An instance in which an individual is between two hyper-intelligent members of the gender he/she is interested in banging. The sandwich of knowledge is a major turn on for the individual, who generally finds super smart hotties irresistable. The sandwich may or may not become sexual.
Dude, last night, I was in the middle of the BEST sexy sandwich of knowledge.
by cafN8edpenguin March 09, 2010

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