Top Definition
Noun: Down Syndrome received by having sexual intercourse with a retard who appears to be suffering from Down Syndrome whether or not he actually does suffer from Down Syndrome.

Usually it's just a faggot who thinks he's hot shit.
"Lindsay" Lohan caught Sexually Transmitted Down Syndrome (STDS) from having sex with that one douche Matthew.
by Landon Smithismith June 10, 2008

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