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Sp.o.u.s. 

Spiders of unusual size obviously gnawing on too many apartment bugs
The SP.o.u.s. that landed on my ass while taking a nap freaked me out.
Sp.o.u.s. by lamarmalaide April 18, 2018
Related Words
At Luther College (Decorah, IA) refers to a campus security officer since they hang around the SPO's a lot.
Hide! There's a spo cop coming!
spo cop by Jon Hoffman September 25, 2005
The best seats in a movie theater. These are the two middle seats of the row 1/3 of the way from the front of the auditorium to the back (in general). In a well-designed theater, these seats are the best, regarding picture (best view), and sound (where the 5.1 speakers are concentrating their sound). ("spo" is believed to stand for "sound pressure optimal".)
Person N-1: So, where are we sitting?
Person N: Spo, of course. Why else would we get here 45 minutes early?
spo by ChuckChaser69 April 30, 2008
(n.) At Luther College (Decorah, IA) SPO stands for "Student Post Office" and is used to refer to an individual's mailbox.
Hold on while I check my SPO.
spo by Jon Hoffman September 25, 2005
Nickname for a guy who is a piece of shit. As in his parent's should've pulled out.
Jacko is kissing ass again. What a Spo
spo by P Tiddy July 13, 2004
SITE PROTECTION OFFICER - Makes less than the guy that takes out the trash
"The SPO will always prevail"
SPO by SPO Hackenburg January 13, 2009