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Usually refers to a quick-time push-button event in video games. Also can refer to any quickly repeated process or action.
Example 1:

Gamer: Gah, I hate this push X not to die sequence! I always die!

Example 2:
Guy 1: My girlfriend's mad at me, but I always get her some flowers and she calms down.

Guy 2: Press X not to die, dude.
by Mikrin262 February 26, 2011