Top Definition
The deep sad nostalgic feeling of departure you feel when your best friend tells you he/she has to go or feeling sleepy after a good conversation usually on Skype or any other IM app.
You : So, what's up?
Friend : My eyes are closing, I need to go to catch some sleep.
Good night :)
You : good night ..
Post-Goodbye depression.
by Alain Kribler May 01, 2014
6 Words related to Post-Goodbye Depression

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