The feeling that your brain has turned into, well.. mush. But something gooier than that. Just kind of a liquid substance. It's basically brain juice with a tiny lump in the upper left-hand corner of your mind, a couple of inches away from the brain stem.
Guy one: "Have you ever gotten so drunk that your brain felt fuzzy?"
Guy two: "Yeah, once it was so bad that my brain felt like plubugup. Though I was tripping on acid at the same time."