When pimples and cheese mix together.
This could be the after affect of:
-a rough night
-drinking with friends
-passing out in a grocery store
or
just plain stupidity.

Could be used as a comparison.

Pimples and Cheese also make a good random rhyme.
Good to use when stuck in a rap battle... for example:
Yo, yoyo, check it, one two, one two.. give it up yo... aight please, I need some pimples and cheese.

or..

Pimples and Cheese, Pimple's and Cheese, yo what you know about Pimples anc Cheese.

comparison - "Yo man, it smells like pimples and cheese"
- funny
by Pimples&Cheese February 2, 2010
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