Top Definition
When a fat, ugly woman with a lot of money still looks like Oprah Winfrey. It doesn't matter how many face lifts or fancy clothes or jewelery she wears, she still looks like the maid or the cook.
That woman suffers from the Oprah Syndrome, she has a lot of money but she still looks like the fat smelly maid.
by Mikey Boyer July 02, 2011

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