1. To be absolutely fucked as a cunt from drugs.
2. To be crazy.
3. To be sick of or 'over' the nut that you are currently eating.
Is also commonly said 'Off Ya Nugget'.
2. Tom was declared 'Off His Nut' when he saw an alien steal his baby.
3. I believe that I am now 'Off My Nut', this 3ft peanut is too salty.
I was 'Off Me Nugget' last night, getting rude like a rumpig.