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1.
The feeling you get when you've done something in excess, akin to the feeling you get after eating 20 chicken nuggets from McDonalds.

The phrase can be used to describe everything from eating too much food to how you feel after a heavy night of drinking.
"I should not have had that bottle of tequila last night, I've got massive nugget regret today."
by canadianmike October 12, 2011