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Defeat; disappointment mixed with acceptance. It is a cute way to express sadness after something unfortunate happens. Word is Japanese in origin.

Nyoro~n originated in a spinoff comic strip called "Nyoron☆Churuya-san" by Utsura Urarak, based on the character of Tsuruya from the anime "The Melancholy of Haruhi Suzumiya". The strip was later expanded into 13 two-minute episodes which are available on youtube by searching "Nyoro~n Churuya-san"; Watching one of these episodes is the best way to understand, through context, what the word means.

Nyoro~n is said in a cute, sad tone of voice after something unfortunate happens. The character who says it is a cute little girl who constantly fails to achieve what she sets out to do (often her goal is to get some smoked cheese).

People who use this word are probably either fans of the Haruhi series and its spinoff, or trying to look really cute, or both.
Try to get change from a vending machine.
It gives all pennies.
"Nyoro~n"

Set out for a picnic.
It starts to rain.
"Nyoro~n"
You eat the food in the rain anyway.

You: Hello Best Friend, I got you some smoked cheese for your birthday!
Best Friend: I am lactose intolerant.
You (crestfallen): Nyoro~n...
You: Don't worry, I'll get you something even better, then!
Best Friend: But there is nothing better than smoked cheese.
You (realizing they are right): Nyoro~n...
Nyoro~n by NyoronTsuruya January 7, 2012
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At the beginning of every r&b song in the 90s
nayoo by Shaun147 March 20, 2017
Related Words
nayrovie namorod naoro nayoko nayoo Nayoon nayorbe Nayrobis nayrobie nayron
A Japanese word, also used in the English language, that is used to silently say "Fuck you" to someone. 90% of the time, the person using it does not get caught.
Person: How do I make smoked cheese?
Person2: Google it.
Person: Nyoron~
Person2: What?
Person: Nothing, thanks.
Nyoron by ThisMahPseudonym March 19, 2009

government created killer nanorobot infection 

a serious epidemic which is now known as GCKNI (Government Created Killer Nanorobot Infection)

Can be spotted by the little red marks all over their bodies resembling freckles.
Those poor people who were involved in the outbreak of GCKNI (Government Created Killer Nanorobot Infection) will never be the same.
No, shes not Japanese. But she is the most fucking beautiful woman in the room. She puts other women to shame, bitches will often start beef with her for no reason other than jealousy. But on top of being beautiful shes also super fucking cool and funny. Definitely a once in a lifetime girl.
nayoko by uhhhhhhhhhhhhhhhhidk April 15, 2019
Nayrobie she is a kind and awesome person. She always makes people smile and laugh she is someone you would want to be friends with, But she does get mad pretty easily so beware of that lmao. Shes a very pretty girl and is so beautiful
girl-“hey look it’s nayrobie”
girl 2-“ yeah shes an amazing person
nayrobie by ilysm <333 December 20, 2021
it's not going left or right or up or down or forward or backward it's staying right where you are bc everything is perfect. It's the direction you go when you're looking at a sunset or when you're on top of a mountain or when you're doing something and you don't wanna stop or with someone and you don't wanna leave
When you see or do something incredible you have made it to nayorbe.
nayorbe by al-la September 4, 2016