Top Definition
(noun) Much like the females camel toe, the mouse knuckle is formed by a male having his pants to tight, showing his meat and two veg through his pants.

Mel: "Look at that guys mouse knuckle, he's not packing much"


Corey: "These emo pants are giving me a wicked mouse knuckle."

by distiller September 13, 2008
Also known as the 'camel toe', this is the female frontal wedgie.
Check out the mouse knuckle on that chic. I can almost see her uterus.
by Perris Bueller May 02, 2005

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