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1.
To have an addicction, especially a drug addiction.
Man, he's got a monkey on him back! He's so wasted!
by bluestorm100 March 12, 2005
241 102
 
2.
To have some very burdensome nuisance you have to put up with--in a sense wider than just a drug or other addiction.
"That huge credit card payment is a real monkey on his back." "Trying to sell that white elephant must be a monkey on your back."
by Guthlac A February 09, 2010
169 68
 
3.
To have a deep, uncontrollable desire to something such as Gamble, Smoke, or Drink.
Man he has that Drinking monkey on his back, it is 9:30 in the morrning and he's already drunk.
by Stan, Ricky, Cody, and Alex April 03, 2003
153 100
 
4.
Addiction, mostly heroin/morphine addiction.
Hey dad, you been smacking da H again, quit it bitch, you have a monkey on your back

But the morphine eased the pain,
And the grass grew round his brain,
And gave him all the confidence he lacked,
With a Purple Heart and a monkey on his back.

There's a hole in daddy's arm where all the money goes,

-John Prine - 'Sam Stone' a song about a vietnam vet returning to the US with a monkey on his back.
by GG Allin11 September 01, 2013
4 3
 
5.
Severe relentless back pain one gets during opiate withdrawal.
hardest part of detox will be the monkey on your back
by XsubZ April 16, 2010
37 88