Top Definition
A metaphor for having done something you regret and can't take back. As with too much alcohol, the more Mistake Whiskey you consume, the worse you feel; especially the next day. Coined by J. Jacques in his webcomic Questionable Content.
"I had already drunk three quarters of the bottle of Mistake Whiskey, so I figured I might as well finish the whole thing."
by Born Blitzed January 03, 2007

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