1. When used as a compliment, it means the same thing as "sick" "cool" or "awesome"

2. When used as a diss, it means that a male's genetalia is overly small, like that of a newly born baby.
"That pussy was so good it was fucking miloscrill"

"Hey Rat, is it cold out? You're as miloscrill as a fucking baby"
by sourdude13 January 12, 2006
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