Top Definition
An overweight person who uses meth. Most tweekers are skinny but you get the rare ones that still eat. They are fat like a hippopotamus.
Look at that fat chick with the sores on her face. She must be a methapotomus. I bet her name is Methany the Methadone Methapotomus.
by Chefdawg8 February 20, 2010

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