Top Definition
1. A night where one drinks an insane amount of alcohol and will eventually pass out. Can be paired with Mega to make a Mega-McGarry night (for a night you will never remember and will probably end up in the hospital) or with Mini to make Mini-McGarry (for a night that you only get a little shit faced). Not to be used lightly.

Named for a certain Physics teacher who enjoys mean Manhattans and keeps a fridge in her room for "experiments" with ethanol. She also failed a Physics lab in college to go to happy hour.
1. Damn, it was a Mega-McGarry night last night. Shit man, what happened?
by MrMcGee February 11, 2008

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