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1. To fail at the most simple of tasks.

2. To mess up an otherwise cakewalk scenario.
1. Woah, dude. You just Mayreni'd that big time.

2. How did you miss that headshot? That guy is AFK!!! Way to MAYRENI!!
by Justice_Avenue February 08, 2010
A beautiful young teenager
Alan:Yo that girl yesterday at the party was a Mayrenis
by Jdiklover July 04, 2009