Top Definition
The asking of stupid questions.
manny: How do I plug in a Wii remote?
Random 1: Dude are you stupid?
Random 2: Wii remotes are wireless...
Steven: What is a PS3?
Random 1 and 2: You have manny syndrome Steven.
by MannySyndrome December 28, 2010
1 more definition
A small penis backed up by a BIG ego.
That boy got manny syndrome!!
by BoomBoomChick August 02, 2008

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