Top Definition
To drive up and back down main street in Manayunk while intoxicated and shout vulgar and vile things at shobies and/or customers of all restaurants on Main Street.

Roxborough, PA has been linked to starting the Manny Loop
Hey bro, do you want to do a Manny Loop before we go to the party?
by DipsetBuhls November 29, 2011

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