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lose your cool 

When somebody is winding you up and you are trying not to let them see how much they're winding you up, you're keeping your cool. When a situation is difficult or stressful, but you're not letting the demands of the situation affect you, you are keeping your cool. If you do finally explode, implode or crumble under the pressure of a situation, you 'lose your cool' and thus lose control of your emotions.
"If that prick keeps on winding me up, I'm gonna smack him."
"Hey, relax. He's doing it on purpose, Don't lose your cool or he'll know he's got to you."

lose your marbles

Lose your marbles = lose one's mind, insanity, person who does not have common sense/wits.
"Lose your marbles"
I knew she'd eventually lose her marbles = I knew she'd eventually lose her common sense/rational mind

Have you lost your marbles?. Means the same as "Have you lost your mind"?

Lose Your Shit 

(verb) -
to spaz out, lose control/sanity, triggered by either some good shit, like music, food, liquor, etc.

the equivalence of going Ape Shit, only non-violently.
"I've got stuff to make you lose your shit"

"soon as that bassline hit, he lost his shit."

"hit me with that Nathan's, just about ready to lose my shit."

Lose Your Shit by last one in April 10, 2009

Lose your muffins 

To be agitated to a point of hysteria.
"Calm down, Werner! You can't do anything about your favorite team losing the championship game. Don't lose your muffins over it."
Lose your muffins by silvermoons October 5, 2009

Lose Your Dnim 

The title for Teen Wolf: Season 3b. It sums up what happened to one of the main characters: Stiles Stilinski. He becomes possessed by an evil Japanese spirit known as the Nogitsune, or Void Kitsune, and goes insane- becoming trapped in his own mind. His body, under the control of the Nogitsune, goes on a homicidal rampage with the Oni, (ancient shadow samurai), feeding on pain and destruction- of which the Nogitsune gets pleasure from.
Jeff: Get ready for Season 6! The last Season! You might just...Lose Your Dnim...
Me: Damnit Jeff.
Lose Your Dnim by Void_Ludwig September 3, 2016

lose your lunch

The act of vomiting. See ralph chunks
Dusan, stop drinking. You look like you're about ready to lose your lunch.
lose your lunch by Wiseman June 27, 2006