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When someone takes an unusually long route to reach their destination.
Person 1: So i'm gonna cut through 42nd street, back down to 48th, do circles in the parking lot and drive Miss Daisy through this neighborhood.

Person 2: How about you just take a left here and we'll be there?

Person 1: Que?

Person 2: You seriously have Long Route Syndrome.
by GeeTee March 07, 2013