1.A quote from the television show Family Guy.

2.A way of saying "SUCK IT", but in a way to parody the extremely popular Star Trek series. Playing off of Dr. Spock's classic catch phrase "Live long and prosper".

3. A more humorous way of telling someone to go fuck themselves.
Nerd: You're Spock costume isn't accurate at all. The ears are poorly made and the uniform is the wrong shade of blue.

Nerd that isn't a total prick: Well, you can go LIVE LONG AND SUCK IT!!
by Gun Stock June 1, 2011
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Spoken by Sheldon Cooper on "The Big Bang Theory", a nod to the most quoted line "Live Long and Prosper" by the late Leonard Nimoy, portraying his famous role as Star Trek's Commanding Science Officer, Mr. Spock. Zachary Quinto reprised the SPOCK role in the 2009 Star Trek reboot .
In a Season 5 episode of "Big Bang", Sheldon, who was expecting a life-sized cutout of Nimoy's Spock but received Quinto's apparently inferior version instead, griped Live Long and Suck It, Zachary Quinto!
by KImCobain March 25, 2015
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