A large line of ketamine, enough to put the user in a 'K-Hole' or enough to incapacitate. One typically has to psych up beforehand or receive moral support.
Steve upon entering room and seeing sprawling human mess : "'Fucks up with him?"
Tony : "Ah, nowt mate. Just gave him a life changer, that's all"
by cumblaster May 06, 2011

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