Top Definition
A combination of, but not limited to, Adderall, Vyvanse, Cocaine, Marijuana, and Percocet. These ingredients must be ingested within one hellacious night, often proceeded by playing unheard-of amounts of guitar, to be considered a true "Lethal Cocktail."
Dear lord man.. that lethal cocktail almost killed us.

What did we just fucking do? That'd be a lethal cocktail bro.
by Dick Ironhammer October 31, 2010

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