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Louisiana School for Math, Science, and the Arts.

1) A state-wide residential magnet school for Louisiana's gifted and talented students of grades 11 and 12 located on the campus of Northwestern State University in Natchitoches.

2) A school with many fine looking girls, hard academics, and has more drama than Laguna Beach.
David: Hey Jake, did u hear about this magnet school called LSMSA?

Jake: Yea, I heard its a tough school, but the girls are hot.
by MeriwetherBR06 November 19, 2005
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An extremely intelligent young lass or lady that has attended the Louisiana School for Math, Science, and the Arts. The equivalency of MIT for high school.
That nigga so smart he could've gone to LSMSA.
by Da Man with a Plan July 24, 2008
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