Someone who is completely thick and/or slow. They find it hard to understand normal people's conversations and jokes. Basically, they are retards. Often used in secondary schools across the UK.
I think my brother has James Syndrome
by Jinab July 30, 2006
The mindstate of being in a stupor mode. Or in simplier form, a mindstate of slowness where the brain literally slows down for x amount of time. This mind state is extremely dangerous and people suffering from this kind of syndrome....well it's too late for them now.
When you "IM" a person, and said person doesn't reply or respond to you it means he/she has the James Syndrome. If that's the case you should inform them and tell them to seek professinal help.
by blah May 17, 2004