Top Definition
A condition where the scrotum becomes itchy and irritable. Pain is minimal, but often causes the victim a lot of discomfort.
Dude, why are you fiddling with your pants?

Oh I got Itchy Scrot Syndrome so bad, my nuts are itching like crazy!
by Ginny P May 09, 2004
1 Word related to Itchy Scrot Syndrome

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