Top Definition
The annoying discomfort resulting from your thong rubbing your booty the wrong way.
Lisa: “You don’t look happy, what’s wrong?.”

Cynthia: “I bought this lace-trimmed thong because it was really cute, but it’s giving me a terrible case of Irritable Thong Syndrome (ITS).”
by kraftgirl September 30, 2009
5 Words related to Irritable Thong Syndrome (ITS)

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