Top Definition
The annoying discomfort resulting from your thong rubbing your booty the wrong way.
Lisa: “You don’t look happy, what’s wrong?.”

Cynthia: “I bought this lace-trimmed thong because it was really cute, but it’s giving me a terrible case of Irritable Thong Syndrome (ITS).”
by kraftgirl September 30, 2009
Free Daily Email

Type your email address below to get our free Urban Word of the Day every morning!

Emails are sent from We'll never spam you.