1. To inform someone that the current situation is no longer working.

2. Fuck off.

3. Your not doing it for me anymore, or what you offer is lacking.
The new "it's not me it's you" is "I'll be taking my talents to south beach."

"It wasn't working out so I told her 'I'd be taking my talents to south beach."

"My boss was giving me grief so I said, straight up 'I'll be taking my talents to south beach."

"You don't have kidney beans in this here general store?! Well f-that. I'll be taking my talents to south beach!"

"After the Rolling Stones article, President Obama told General McChrystal he could take his talents to south beach."

It originates when LeBron James turned down the Cleveland Cavaliers offer, on a 1 hour nationally televised special, expressing that he was signing with the Miami Heat. He said "This fall I am taking my talents to south beach."
by Master Alexander July 11, 2010
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