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1.
Do what you got to do. Usually referring to doing something to the fullest extent.
"Lets out for my birthday, I want to get smashed!"
"Handle it!!!
by elybear September 24, 2010
 
2.
Take it like a man and suck it up.
"Bitch why am i stuck with the nig wheel for mario cart?!??!"
"handle it"
by THE BP CHAMP July 10, 2008