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1.
The pain you feel in your hand and wrist after playing Guitar Hero for an extended period of time. Similar to Carpal Tunnel Syndrome.
I was playing Guitar Hero for so long, I was suffering from Guitarpal Tunnel Syndrome.
by Briar P January 08, 2008
 
2.
A type of compression neuropathy (nerve damage) caused by compression and irritation of the median nerve in the wrist after participating in extended Guitar Hero or Rock Band sessions.
Dude, I need to switch to drums or vocals 'cause this guitarpal tunnel syndrome is kicking my butt.
by One Niner January 05, 2009