A guitar simulation game in which a player presses 3 buttons and a pick on a simulated guitar as their corresponding markers reach a line at the top of the screen.
A game in Konami's Bemani series in which you use a controller that looks like a guitar to make music. The controller has three buttons and a pick-thing on it. Also links to DrumMania and used to link to Keyboardmania.
"I played Guitar Freaks a few times, got frustrated because I could never figure out how to hold the controller right, and returned to failing songs on DrumMania."
Anonymous: Hey, wanna play jam session with me?
Random: Sure, as long as I play GuitarFreaks.