Top Definition
A rotten, wretched old lady. Someone's grandmother who is way beyond expiration and/or should be put into a nursing home.

A nasty old woman who treats you like dirt.
Did you hear what that old woman said to me? Seriously, Gramma Karen?!

My boyfriend's Gramma Karen has it out for me. Every time I see her, she always has something rude to say.
by Amanda KKK P November 28, 2010

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