An insane combination of STDs usually used as an exageration when talking about a sexually promiscuous person who has a high likelyhood of acquiring the disease.
It is by definition a combination of: Gonorhea, Syphillis, Herpes. However it could be used to describe any combination of STDs.
1. Tony: She was screwing some other guy last night. That's like the 6th different person this week.
Frank: Yeah she's gonna end up with gonosyphyiherpelis, if she doesn't already have it yet.
Tony: I wouldn't touch that with a 10 foot pole...Sheeeeit.