The act of getting fucked up on pills. Said pills can include Vicodin (hyrdocodone/apap), Norco (stronger hydrocodone/apap) Oxycotin (Oxycodone), Xanax (Alparazolam) etc. This is when you are in a complete state of being fucked up from taking pills, either orally, inter nasally, or even anally.
Ryan: Yo, Steve-O, what you got there?
Steve-O: About 90 Narcos and 120 Xanax.
Ryan: Oh shit, we're gonna be all gnawed out today!