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1.
A girl who is so loose that everytime a penis or phallic object enters her vagina she rips a queef; hence the name; Georgia O'Queef.
George: Jenna is so hot...

Drew: Don't bang her though, she's a real Georgia O'Queef.
by that.boy.is.a.monster February 23, 2010
 
2.
when something queer happens,
"GHEY"
or something goes wrong,
meaning oh bollocks or thats a bit shit
When your pencil breaks you might say
"well that's a bit Georgia O' Queef !"
by Z.R. November 18, 2007