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1.
When a situation arrives that hinders one from participating in events they would normally attend, or would like to attend.

When a person has prior obligations that obscure them from attending an event with their friends.
Guy 1 - "Hey man you gonna make the concert this weekend?"

Guy 2 - "Naw man, doc said I can't leave the house with my broke leg. Really "gaying me down".

"My girlfriend said I can't go to the titter this weekend, really gaying me down over here."
by Pancer Man December 06, 2013