G_nome is the ghetto variation of the biological word genome, which is a human's DNA sequence. The word is used mainly in the description of phat women and fly men who don't have to try to keep it gangsta. The term essentially means that one has fly-ness encoded in their DNA. There has also been a human G_nome project in which Micheal Moore went and did a documentary on life in the ghetto, however he was shot and hospitalized shortly there after.
by dswag3636 January 24, 2007