Top Definition
Sent via text, the acronym "GMFBO" stands for "Giggling My Fucking Balls Off" this acronym is a more vulgar version of saying LOL or LMFAO. This should be used by only men, transgenders or women who also happen to possess testicles
Helen: My parents are idiots! They think I'm going to the football game when I'm actually going whoring around with my slutty friends!

Gene: GMFBO!
by Tommy Littlefoot III May 27, 2012

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