Top Definition
The weapon a person, deity or the universe itself uses when they decide to jerk you around.

Originated on the TV series Dead Like Me.
"I have had the worst week. The universe has really fired the Fuck-With-Me Gun at me."

"Frank decided to give me the collating duties. He's really decided to whip out the Fuck-With-Me gun"
by Mason R. June 10, 2008
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