1) Adjective - The ultimate mistake which ends with disastrous consequences, usually involving multiple parties which were not, directly, involved in the incident. Usually, it starts with a minor, low level, bad decision.
2) Noun - A person who commits the "ultimate" mistake.
The introduction of the Africanized Bee in Brazil in 1957 created consequences that spanned across continents and devastated ecosystems. This is prime example of a "fuck up of the first order".

The person who actually released the bees, or setup the conditions where the bees where released, is also nown as a "fuck up of the first order".
by John43ll October 07, 2011

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