It is the syndrome most girls get (but some boys too) after they "make love" for their first time. And it doesn't matter if the dude/girl they did it with is the biggest loser/idiot/asshole whatever, they will give them every chance in the world no matter what other people say.
Girl: hey, I think I'm gonna give my x another chance.
Boy: Damn girl are you crazy?!? Listen I gotta know somethin. Did you give it up to him?
Girl: ya
Boy: Aahh damn girl thats why you keep giving him chances, you got that First Fuck Syndrome!
by Ferd to the Word April 30, 2009
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When a woman loses her virginity, the resulting condition that causes an irrational feeling of attachement and love towards her current partner. The severity of this disease should not be underestimated. It can also extend beyond the termination of said relationship. In unusual and rare circustances, it has been known to affect effeminate men as well.
"Wow, he told all her friends he hates her, cheated on her, got with her best friend the day after they broke up, but she is still telling everyone that she wants to be with him, and that he's perfect for her."

"Yeah, that girl is really First-Fuck-Syndromed."
by S.D. and S.W.A. January 31, 2005
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