Top Definition
Fat Cow Disease- AS in Mad cow disease one generally loses the ability to remember and think clearly...In fat Cow disease one has an inability to not only think clearly but also perform simple functions such as wearing low rise jeans.

2. A sense of onself feeling lethargic, physically and mentally useless due to a sudden and unexplainable weight gain
Those blue jeans look like they should be on shamu! Judging by those jeans, she has fat cow disease!

2. Geez, I can't get up off the couch today and I can barely write my name. My fat cow disease is kicking in!
by Connie Etn February 03, 2010

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