Top Definition
That period of time around the last couple weeks of classes and during exam week where you feel so overloaded and stressed that you would rather lay in bed with cookie dough ice cream and watch Family Guy than do anything productive. This is a very dangerous condition that may result in severe loss of motivation, feelings of helplessness, poor diet, weight gain, exhaustion, and the end of the world.
"Hey, girl, are you excited for the end of classes?"

"Bitch, please, I am going through some severe End-of-Semester Depression. There is no way I can get all of my shit done."
by Bobbi B. April 30, 2013

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