Insensitive Michigan slang for a genetic disposition of women with ancestors from the Netherlands towards posterior adiposity (a fat ass).
Yikes, They better start crop-dusting for Dutch Butt Disease or there won't be any seats left on the buses.
by Mitch Gander January 19, 2005
A bad case of gas, indigestion, or diarrhea that can attack people of anglo-dutch ancestry
Girl: I don't feel like doing anything sexual tonight; I ate too much and I'm getting a bad case of dutch butt disease
by Joran van der Sloot March 10, 2008