Top Definition
A disease contracted from playing Duke Nukem for an extended period of time.

Side effects include:

- Constant sexual innuendos
- Thinking you're tougher than you actually are
- Swearing. A LOT
- Talking in a low, raspy voice
Joe: Hey man, what's up?
Tim: Go fuck yourself. I'll rip off your head and shit down your neck.
Joe: What the fuck?
Matt: Don't mind him, he's been playing Duke Nukem Forever for 3 days. He's got a major case of Duke Syndrome.
by TheHurriquake June 18, 2011
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