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1.
Could refer to practically anytime a person has a bowel movement.
John: "Did you have a diarrhea meltdown today?"
Josh: "Yeah, it was purple..."
by NorbalorB April 21, 2011
 
2.
Diarrhea so severe it causes extreme anal burns and a mass destruction on the toilet, which may overflow with burning hot liquid shit.
Ahh dude i had some serious diarrhea meltdown the other night.
by Doktordumpz November 21, 2010