Top Definition
A serious condition in which a male may begin to feel strong sexual attraction to unattractive females after a long period of sexual inactivity. The condition can be alleviated through the use of masturbation, but this will only help for 2-3 hours, 2-3 times per day.
Having not had sex since March 8th, 2006, Johnny developed Desperate Dick Syndrome and began lusting after fat girls.
by Collin Jones September 18, 2007

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