A disease (perhaps contagious) symptomized by using continuous "derp" actions.
"Man, I think Micheal has derpies."
"I know a few people who certainly have derpies."
by Lsh14 April 27, 2010
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The bottom half of the reproductive organ on the women, or the vagina.
by CaptainFaggot February 3, 2012
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A highly contagious disease originating from John Lane.
This disease is spread through acts of sheer stupidity, and there is no known cure.
Dammit, John touched me funny style and now I have da derpies
by RamstainAU September 26, 2010
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It's like a selfie but for derps or moments of derpness.
I look like a derp in my selfie. #derpie
by Lopaka May 3, 2014
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(noun) 1. the unfortunate condition of permanent ugliness whose contorted nature is often misconstrued with the common phenomena of "herp-derping"
2. a title for someone who is often seen "herp-derping," whether in photographs or in real life
3. a good way to troll, or fool, others into admitting to embarrassing and most likely untrue diseases
1. Jake: "Dude, what's up with Todd's face?"
John: "I don't know man, he looks like he's herp-derping."
Todd: "Herrrrrrrrp, I have derpies."

2. Sam: "You ever notice how Todd is always derping in pictures?"
Chris: "Yeah, it's weird, I wonder if he has derpies."
Todd: "Herrrrrrrp, I have derpies."
Sam: "You don't say...."

3. Troll: "Herp, I have derpies."
Victim: "Oh yeah? Well, derp, I have herpies."
Crowd: "Booh!" "Get off the stage!"
Victim: "FFFFFFFFFFFUUUUUUUUUUUU...!"
by githeroter December 3, 2012
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When your crabs have herpes.
Oh man that dude has a horrid case of derpies.
by LIONwho March 29, 2011
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1. adj lacking intelligence; no common sense

2. adj used to describe a person who acts stupidly or often messes up
Man, was Leo acting derpy today.
by Future Echo January 1, 2017
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